The leadership of AMBSO is headed by the Board of Directors (BOD) composed of Ugandan research scientists and founders of the institution. The BOD is steered by the Executive Director who is as well as the Chairperson of the BOD, and works hand in hand with the Senior Management Team (SMT) headed by the Program Director. The SMT is supported by the various departments led by the respective Heads of department who provide day-to-day technical oversight of the various research and program activities.